This review covers natural products reported by studies on from the Brazilian endophytic fungi cultures and classified them into three chemical classes (terpenes, phenolic, and nitrogen-containing compounds). The extraordinary richness of the Brazilian biodiversity has encouraged several research groups in the endophytic bioprospecting. They display wide biosynthetic capacity when producing several bioactive secondary metabolites, whose induction could be related to activation of genes, which might be silent or expressed depending on the geographic characteristics from where the endophytic was isolated. Endophytes are microorganisms that live inside vegetal tissues without causing any loss to the host plant.
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